It has been reported that fatty acids preferentially inhibit serum-stimulated incorporation
of sulfate by embryonic chick cartilage, suggesting that they may interfere with the
effects of a proposed mediator (serum somatomedin) of the actions of growth hormone
(GH). This was studied further in mammalian cartilage. Butyrate and octanoate at concentrations
of 0.5 to 5 mM produced a concentration dependent inhibition of both basal and serum-stimulated
sulfate and thymidine incorporation by costal cartilage from hypophysectomized rats.
Butyrate also inhibited basal and serum-stimulated sulfate incorporation in cartilage
from normal pigs and normal suckling rats. In all 3 test systems, oleate (0.2-5 mM)
bound to serum albumin (4 g/dl) was ineffective. There was no evidence that fatty
acids preferentially inhibited the stimulation of sulfate incorporation produced by
serum.
Sulfation Factor (Somatomedin) - Fatty Acids - Cartilage
